"Sharing is sometimes more demanding than giving"
-Mary Catherine Bateson
-Mary Catherine Bateson
2013
Pérez Morales TG, Ho TD, Liu WT, Dorrestein PC, Ellermeier CD. Production of the Cannibalism Toxin SDP is a multi-step process that requires SdpA and SdpB.
J Bacteriol. 2013 May 17.
Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore BS. Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic GeneCluster in Salinispora tropica. Chembiochem. 2013 May 27;14(8):955-62.
Rath CM, Yang JY, Alexandrov T, Dorrestein PC. Data-Independent Microbial Metabolomics with Ambient Ionization MassSpectrometry. J Am Soc Mass Spectrom. 2013 Apr 9.
Sanchez LM, Dorrestein PC. Analytical chemistry: Virulence caught green-handed.Nat Chem. 2013 Mar;5(3):155-7.
van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthaseaffects antibiotic sensitivity and skin abscess development. J Biol Chem. 2013 Mar 1;288(9):6417-26.
Watrous JD, Phelan VV, Hsu CC, Moree WJ, Duggan BM, Alexandrov T, Dorrestein PC. Microbial metabolic exchange in 3D.ISME J. 2013 Apr;7(4):770-80.
Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein PC, Milla ME. A highly efficient, high-throughput lipidomics platform for the quantitativedetection of eicosanoids in human whole blood. Anal Biochem. 2013 Feb 15;433(2):181-8.
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide naturalproducts: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan;30(1):108-60.
Ross AC, Xu Y, Lu L, Kersten RD, Shao Z, Al-Suwailem AM, Dorrestein PC, Qian PY, Moore BS. Biosynthetic multitasking facilitates thalassospiramide structural diversity inmarine bacteria. J Am Chem Soc. 2013 Jan 23;135(3):1155-62.
2012
Young TS, Dorrestein PC, Walsh CT. Codon randomization for rapid exploration of chemical space in thiopeptideantibiotic variants. Chem Biol. 2012 Dec 21;19(12):1600-10.
Song J, Liu X, Wu J, Blevitt JM, Dorrestein PC, Milla ME., A Highly Efficient, High-Throughput Lipidomics Platform for the Quantitative Detection of Eicosanoids in Human Whole Blood. Anal Biochem. 2012 Oct 25.
Hollands A, Gonzalez D, Leire E, Donald C, Gallo RL, Sanderson-Smith M, Dorrestein PC, Nizet V., A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides.J Biol Chem. 2012 Oct 4.
Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC., Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Anal Chem. 2012 Nov 6;84(21):9259-67.
Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick WH., Viequeamide a, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. J Nat Prod. 2012 Sep 28;75(9):1560-70.
Moree WJ, Phelan VV, Wu CH, Bandeira N, Cornett DS, Duggan BM, Dorrestein PC.,Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13811-6.
Hoefler BC, Gorzelnik KV, Yang JY, Hendricks N, Dorrestein PC, Straight PD., Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13082-7.
Yang JY, Phelan VV, Simkovsky R, Watrous JD, Trial RM, Fleming TC, Wenter R, Moore BS, Golden SS, Pogliano K, Dorrestein PC., Primer on agar-based microbial imaging mass spectrometry. J Bacteriol. 2012 Nov;194(22):6023-8.
Roberts AA, Schultz AW, Kersten RD, Dorrestein PC, Moore BS., Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. FEMS Microbiol Lett. 2012 Oct;335(2):95-103.
Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC., Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30;75(16):5069-76.
Guthals A, Watrous JD, Dorrestein PC, Bandeira N., The spectral networks paradigm in high throughput mass spectrometry. Mol Biosyst. 2012 Oct;8(10):2535-44.
Watrous J, Roach P, Alexandrov T, Heath BS, Yang JY, Kersten RD, van der Voort M, Pogliano K, Gross H, Raaijmakers JM, Moore BS, Laskin J, Bandeira N, Dorrestein PC., Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1743-52. Epub 2012 May 14.
Lamsa A, Liu WT, Dorrestein PC, Pogliano K., The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and induces autolysis. Mol Microbiol. 2012 May;84(3):486-500. doi: 10.1111/j.1365-2958.2012.08038.x. Epub 2012 Apr 2.
Xu Y, Kersten RD, Nam SJ, Lu L, Al-Suwailem AM, Zheng H, Fenical W, Dorrestein PC, Moore BS, Qian PY., Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc. 2012 May 23;134(20):8625-32. doi: 10.1021/ja301735a. Epub 2012 Apr 6.
Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V., Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20;287(17):13889-98. Epub 2012 Feb 27.
Rath CM, Dorrestein PC., The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes. Curr Opin Microbiol. 2012 Apr;15(2):147-54. Epub 2011 Dec 30. Review.
Phelan, V., Liu, WT., Pogliano, K., Dorrestein, PC., Microbial metabolic exchange--the chemotype-to-phenotype link. Nature Chemical Biology, 2011 Dec 15;8(1):26-35.
2011
Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC., A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Oct 9;7(11):794-802.
Liu WT, Kersten RD, Yang YL, Moore BS, Dorrestein PC., Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin in Streptomyces roseosporus. J Am Chem Soc. 2011 Nov 16;133(45):18010-3. Epub 2011 Oct 24.
Watrous JD, Dorrestein PC., Imaging mass spectrometry in microbiology. Nat Rev Microbiol. 2011 Aug 8;9(9):683-94.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG., ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs. Cell. 2011 Nov 11;147(4):773-88.
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP., Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 2011 Oct 26;478(7370):542-6.
Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C.,Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chem Biol. 2011 Aug 26;18(8):1021-31.
Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA., Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res. 2011 Oct 7;10(10):4505-12.
Esquenazi E, Daly M, Bahrainwala T, Gerwick WH, Dorrestein PC., Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation. Bioorg Med Chem. 2011 Nov 15;19(22):6639-44. Epub 2011 Jul 1.
Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH., Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod. 2011 Aug 26;74(8):1737-43. Epub 2011 Jul 13.
Mohimani H, Yang YL, Liu WT, Hsieh PW, Dorrestein PC, Pevzner PA., Sequencing cyclic peptides by multistage mass spectrometry. Proteomics. 2011 Sep;11(18):3642-50. Epub 2011 Aug 9.
Jones CS, Esquenazi E, Dorrestein PC, Gerwick WH., Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry. Bioorg Med Chem. 2011 Nov 15;19(22):6620-7. Epub 2011 Jun 14.
Gonzalez DJ, Haste NM, Hollands A, Fleming TC, Hamby M, Pogliano K, Nizet V, Dorrestein PC.,Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Microbiology. 2011 Sep;157(Pt 9):2485-92. Epub 2011 Jun 30.
Yang YL, Xu Y, Kersten RD, Liu WT, Meehan MJ, Moore BS, Bandeira N, Dorrestein PC.,Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5839-42. Epub 2011 May 13.
Jones AC, Monroe EA, Podell S, Hess WR, Klages S, Esquenazi E, Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR 3rd, Reinhardt R, Kube M, Burkart MD, Allen EE, Dorrestein PC, Gerwick WH, Gerwick L.,Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8815-20. Epub 2011 May 9.
Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH., Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One. 2011 Apr 12;6(4):e18565.
Kalaitzis JA, Cheng Q, Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, Moore BS.,Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem. 2011 Nov 15;19(22):6633-8. Epub 2011 Apr 16.
Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore BS., Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol. 2011 Jun;77(11):3617-25. Epub 2011 Apr 15.
Mevers E, Liu WT, Engene N, Mohimani H, Byrum T, Pevzner PA, Dorrestein PC, Spadafora C, Gerwick WH., Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod. 2011 May 27;74(5):928-36. Epub 2011 Apr 13.
Engene N, Choi H, Esquenazi E, Rottacker EC, Ellisman MH, Dorrestein PC, Gerwick WH., Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol. 2011 Jun;13(6):1601-10. Epub 2011 Apr 7.
Esquenazi E, Jones AC, Byrum T, Dorrestein PC, Gerwick WH., Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proc Natl Acad Sci U S A. 2011.
Bruand J, Sistla S, Mériaux C, Dorrestein PC, Gaasterland T, Ghassemian M, Wisztorski M, Fournier I, Salzet M, Macagno E, Bafna V., Automated Querying and Identification of Novel Peptides using MALDI Mass Spectrometric Imaging. J Proteome Res. 2011 Feb 18.
Watrous JD, Alexandrov T, Dorrestein PC., The evolving field of imaging mass spectrometry and its impact on future biological research. J Mass Spectrom. 2011 Feb;46(2):209-22. doi: 10.1002/jms.1876.
Dorrestein PC, Carroll KS., 'Omics' of natural products and redox biology., Curr Opin Chem Biol. 2011 Feb;15(1):3-4.
Yang JY, Karr JR, Watrous JD, Dorrestein PC., Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes. Curr Opin Chem Biol. 2011 Feb;15(1):79-87.
Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein PC., FT-ICR-MS Characterization of Intermediates in the Biosynthesis of the α-Methylbutyrate Side Chainof Lovastatin by the 277 kDa Polyketide Synthase LovF. Biochemistry. 2010
Meier JL, Patel AD, Niessen S, Meehan M, Kersten R, Yang JY, Rothmann M, Cravatt BF, Dorrestein PC, Burkart MD, Bafna V., Practical 4'-phosphopantetheine active site discovery from proteomic samples. J Proteome Res. 2011 Jan 7;10(1):320-9.
Mohimani H, Liu WT, Yang YL, Gaud Ncio SP, Fenical W, Dorrestein PC, Pevzner PA., Multiplex de novo sequencing of Peptide antibiotics. J Comput Biol. 2011 Nov;18(11):1371-81. Epub 2011 Oct 28.
Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA., Cycloquest: Identification of Cyclopeptides via Database Search of Their Mass Spectra against Genome Databases. J Proteome Res. 2011 Oct 28.
2010
Liu X, Inbar Y, Dorrestein PC, Wynne C, Edwards N, Souda P, Whitelegge JP, Bafna V, Pevzner PA., Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach. Mol Cell Proteomics. 2010 Dec;9(12):2772-82.
Kersten RD, Dorrestein PC., Metalloenzymes: Natural product nitrosation. Nat Chem Biol. 2010 Sep;6(9):636-7.
O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM., Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS One. 2010 Jul 22;5(7):e11716.
Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG., PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22;466(7305):508-12.
Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez D, Ellermeier CD, Straight PD, Pevzner PA, Pogliano J, Nizet V, Pogliano K, Dorrestein PC., Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16286-90. Epub 2010 Aug 30.
Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC., Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 3;285(36):28220-8.
Leao PN, Pereira AR, Liu WT, Ng J, Pevzner PA, Dorrestein PC, Konig GM, Vasconcelos VM, Gerwick WH., Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11183-8.
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL., A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11;285(24):18516-27.
Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y.,Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis. J Am Chem Soc. 2010.
Watrous J, Hendricks N, Meehan M, Dorrestein PC., Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry. Anal Chem. 2010 Mar 1;82(5):1598-600. PMID: 20121185
Jones AC, Gerwick L, Gonzalez D, Dorrestein PC, Gerwick WH., Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol. 2009 Dec 1;9:247. PMID: 19951434
Watrous, J., Burns, K. Liu, W., Patel, A., Hook, V. Bafna, V. Barry3rd C. E., Bark, S., Dorrestein P. C., Expanding the Mycobacterial Pupylome. Molecular Biosystems, 2010 Feb;6(2):376-85.
2009
Yang, Y.L., Xu, Y., Straight, P., Dorrestein, P.C., Translating metabolic exchange with imaging mass spectrometry. Nature Chemical Biology ,2009 Dec;5(12):885-7.
Esquenazi, E., Yang, Y-L., Watrous, J., Gerwick, W. H., Dorrestein, P. C., Imaging Mass Spectrometry of Natural Products. Natural Product Reports, 2009, Dec;26(12):1521-34. Epub 2009 Nov 9. Review. (featured on the cover)
Ng,J., Bandeira, N.,Liu, W.T. Ghassemian, M., Simmons, T. L., Gerwick, W.H., Linington, R., Dorrestein P.C., Pevzner, P., Dereplication and De Novo Sequencing of Nonribosomal Peptides. Nature Methods, (2009), 6(8):596-9. PMID: 19597502
Taniguchi M., Nunnery J.K., Engene N., Esquenazi E., Byrum T., Dorrestein P.C., Gerwick W.H.Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine Cyanobacterium Lyngbya majuscula. Nat. Prod. 2009, PMID: 19839606
Kersten R. D, Dorrestein, P. C., Secondary Metabolomics: Natural Products Mass Spectrometry Goes Global. ACS chemical Biology, (2009), Invited commentary, 4(8):599-601.PMID: 19817465
Xie X., Meehan M.J., Xu W., Dorrestein P.C., Tang Y., Acyltransferase mediated polyketide release from a fungal megasynthase. Journal of the American Chemical Society, (2009) 131, 8388-9. PMID: 19530726
Hughes, C, Yang, Y-L, Liu, W-T., Dorrestein, P. C. *, La Clair*, Fenical, W.,* Elucidation of the binding of marinopyrrole A to actin by dye transfer. Journal of the American Chemical Society, (2009),131(34):12094-6. PMID: 19673475
Esquenazia E., Dorrestein P. C, Gerwick W. H., Probing marine natural product defenses with DESI-imaging mass spectrometry. Proc. Natl. Acad. Sci. USA. (2009, comm.), 106, 7269-70. PMID: 19416917
Liu, W.T., Ng, Julio, Meluzzi, D., Bandeira, N., Gutierrez, M., Simmons, T., Schultz, A., Linington, R., Moore, B., Gerwick, W., Pevzner, P., Dorrestein, P. C., The structural characterization of cyclic non-ribosomal peptides by tandem mass spectrometry. Analytical Chemistry (2009) 106, 7269-70. PMID: 19413302
Kersten R. D., Meehan M., Dorrestein P. C., Applications of Modern Mass Spectrometry Techniques for the Characterization of Biosynthetic Pathways of Natural Products.Comprehensive Natural Products Chemistry Second Edition. (2009).
OHayre M., Salanga C. L., Dorrestein P.C. and Handel T., Phosphoproteomic Analysis of Chemokine Signaling Networks. Methods in Enzymology (2009), 460,331-46. PMID: 19446733
Burns KE, Liu WT, Boshoff HI, Dorrestein PC, Barry CE 3rd., Proteasomal protein degradation in mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. J Biol Chem. 2009 Jan 30;284(5):3069-75.
2008
Esquenazi, E., Coates, C., Simmons, L., Gonzalez, D., Gerwick, W.H., Dorrestein, P.C., Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Molecular BioSystems. 2008 Jun;4(6):562-70.
Simmons, T. L., Coates R.C., Clark B. R., Engene N., Gonzalez D., Esquenazi, E., Dorrestein P. C., Gerwick W. H., Biosynthetic Origin of Natural Products Isolated from Marine Microorganism-Invertebrate Assemblages. Proc. Natl. Acad. Sci. USA. 2008 Mar 25;105(12):4587-94.
Zhang, J., Van Lanen, S. G., Ju, J., Liu, W. Dorrestein, P.C., Li, W., Kelleher, N. L., Shen, B. A.,Phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. USA. 2008 Feb 5;105(5):1460-5.
Meluzzi, D., Zheng, W.H., Hensler, M., Nizet, V., Dorrestein, P. C., Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorganic & Medicinal Chemistry Letters. 2008 May 15;18(10):3107-11.
Hanes JW, Burns KE, Hilmey DG, Chatterjee A, Dorrestein PC, Begley TP., Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-52.
Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G., A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14;29(5):563-76.
Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE., Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Pouwels LJ, Zhang L, Chan NH, Dorrestein PC, Wachter RM., Kinetic isotope effect studies on the de novo rate of chromophore formation in fast- and slow-maturing GFP variants. Biochemistry. 2008 Sep 23;47(38):10111-22.
2007
Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT., Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol. (2007) Jul;14(7):835-46.
Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore BS., Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem. (2007) Jun 1;282(22):16362-8.
Yin, J., Straight, P.D., Hrvatin, S., Dorrestein, P. C., Bumpus, S., Jao, C., Kelleher, N. L., Kolter, R., Walsh, C.T., Genome-wide high throughput mining of natural product biosynthetic gene clusters by phage display. Chemistry and Biology,(2007) Mar;14(3):303-12.
2006
Garneau-Tsodikova, S., Dorrestein, P.C., Kelleher, N.L., Walsh, C. T., Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society (2006) 128(39); 12600-12601.
Dorrestein, P.C., Kelleher, N.L., Dissecting Non-ribosomal and Polyketide Biosynthetic Machineries Using Electrospray Ionization Fourier-Transform MassSpectrometry. Nat Prod Rep. (2006) Dec;23(6):893-918.
Dorrestein P.C., Bumpus S. B., Calderone C. T., Garneau-Tsodikova S., Aron Z. D., Straight P.D., Kolter R., Walsh C. T. and Kelleher N. L., Facile Detection of Acyl- and Peptidyl- intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions During Tandem Mass Spectrometry. Biochemistry (2006) 45 (6), 1537 -1546.
Dorrestein, P.C., Van Lanen, S. G., Li, W. Zhao, C., Deng, Z., Shen, B., Kelleher, N.L., The Bifunctional Glyceryl Transferase/Phosphatase OzmB Belonging to the HAD Superfamily That Diverts 1,3-Bisphosphoglycerate into Polyketide Biosynthesis. Journal of the American Chemical Society (2006) 128 (32), 10386 10387.
Calderone, C.T., Kowtoniuk, W.E., Kelleher, N.L., Walsh, C.T., Dorrestein, P.C., Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of B. subtilis. Proc. Natl. Acad. Sci. USA. (2006) 103, 8977-8982.
Dorrestein, P.C., Blackhall, J., Straight, P.D., Fischbach, M.A., Garneau-Tsodikova, S., Edwards, D.J., McLaughlin, S., Lin, M., Gerwick, W.H., Kolter, R., Walsh, C.T., Kelleher, N.L., Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry. Biochemistry (2006) 45(6), 1537-1546.
Howarth, M., Chinnapen, D.J.F., Gerrow, K., Dorrestein, P.C., Grandy, M.R., Kelleher, N.L., El-Husseini, A., Ting, A.Y., A Monovalent Streptavidin with a Single Femtomolar Biotin Binding Site. Nature Methods (2006) 3(4), 267-273.
Hicks, L.M., Mazur, M.T., Miller, L.M., Dorrestein, P.C., Schnarr, N.A., Khosla, C., Kelleher, N.L.,Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides using Fourier-Transform Mass Spectrometry. ChemBiochem (2006) 7, 904-907.
Van Lanen S.G., Lin S., Dorrestein P.C., Kelleher N.L., Shen B., Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Biol. Chem. (2006) 281, 29633-40.
2005
Dorrestein, P.C., Yeh, E., Garneau-Tsodikova, S., Kelleher, N.L., Walsh, C.T., Dichlorination of a Pyrrolyl-S-Carrier protein by FADH2-Dependent Halogenase PltA During Pyoluteorin Biosynthesis. Proceedings of the National Academy of Sciences of the United States of America (2005) 102(39), 13843-13848.
Aron, Z.D., Dorrestein, P.C., Blackhall, J.R., Kelleher, N.L., Walsh, C.T., Characterization fo the New Tailoring Domain in Polyketide Biogenesis: The Amine Transferase Domain of MycA in the Mycosubtilin Gene Cluster. Journal of the American Chemical Society (2005) 127(43), 14986-14987.
Van Lanen, S.G., Dorrestein, P.C., Christenson, S.D., Liu, W., Ju, J., Kelleher, N.L., Shen, B.,Biosynthesis of the b -Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring b-Amino Acyl-S-carrier Protein Intermediates. Journal of the American Chemical Society. (2005) 127(33), 11594-5.
Garneau, S., Dorrestein, P.C., Kelleher, N.L., and Walsh, C.T., Characterization of the Formation of the Pyrrole Moiety during Clorobiocin and Coumermycin A1 Biosynthesis. Biochemistry. (2005) 44, 2770-2780.
Zhai, H., Dorrestein, P.C., Chatterjee, A., Begley, T.P., McLafferty, F.W., Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. Journal of American Society of Mass. Spectrometry. (2005) 16(7), 1052-9.
Burns, K.C., Baumgart, S., Dorrestein, P.C., Zhai, H., McLafferty, F.W., Begley, T.P., Reconstitution of a New Cysteine Biosynthetic Pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society. (2005) 127(33), 11602-3.
Dorrestein P.C., and Begley, T.P., Oxidative cascades: a facile biosynthetic stategy for the assembly of complex molecules. Bioorganic Chemistry. (2005) 33(3), 136-148. (review).
2004
Settembre E.C., Dorrestein, P.C., Zhai,H., Chatterjee, A., McLafferty, F.W., Begley, T.P., Ealick S.E., Structure of the ThiS/ThiG complex Essential for Thiamin Biosynthesis in Bacillus subtilis.Biochemistry. (2004) 43(37), 11647-57.
Dorrestein, P.C., Zhai, H., McLafferty F.W., and Begley, T.P., The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin (Vitamin B1): The Sulfur Transfer Mediated by the Sulfur Carrier Protein ThiS. Chemistry and Biology. (2004) 11(10), 1373-81.
Dorrestein, P.C., Zhai, H., Taylor, S., McLafferty, F., and Begley, T.P., The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase.Journal of the American Chemical Society. (2004)126(10), 3091-6.
2003
Kurnasov, O., Jablonski, L., Polanuyer, B., Dorrestein, P.C., Begley, and T.P., Ostermann, A.,Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS microbiology letters. (2003) 227(2), 219-227.
Park, J., Dorrestein, P.C., Zhai, H., Kinsland, C., McLafferty, F.W., and Begley, T.P., Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. (2003) 42, 12430-12438.
Dorrestein, P.C., Poole, K., and Begley, T.P., The formation of the pyoverdine chromophore by an oxidative cascade. Organic Letters. (2003) 5(13), 2215-2217.
Maggio-Hall, L., Dorrestein, P.C., Begley T.P., Escalante-Semerena J. C., Formation of the Dimethylbenzimidazole Ligand of Coenzyme B12 under physiological conditions by a facile oxidative cascade. Organic letters. (2003) 5(13), 2211-2213.
Settembre, E.C., Dorrestein, P.C., Park, J., Augustine, A., Begley, T.P., Ealick, S.E., Structural and Mechanistic studies of ThiO, a Glycine Oxidase Essential for Thiamin Biosynthesis in Bacillus subtilis. Biochemistry. (2003) 42(10), 2971-2981.
1999-2002
Anand, R., Dorrestein, P.C., Kinsland, C., Begley, T.P., Ealick, S.E., Structure of Oxalate Decarboxylase From Bacillus subtilis at 1.75 Resolution. Biochemistry. (2002) 41(24), 7659-7669.
Begley, T.P., Kinsland, C., Mehl, R.A., Ostermann, A., and Dorrestein, P.C. The Biosynthesis of Nicotinamide Adenine Dinucleotides in Bacteria. Vitamins and Hormones (San Diego, CA, United States). (2001) 61,103-119 (review).
Mansour, G., Creedon, W., Dorrestein, P.C., Maxka, J., MacDonald, J.C., Helburn, R., Synthesis and Physical Characterization of Some New Hydrophobic Forms of the Solvatochromic N,N-dialkyl-p-nitroanilines. Journal of Organic Chemistry. (2001) 66(11), 4050-4054.
MacDonald, J.C., Dorrestein, P.C., Pilley, M.M., Design of Supramolecular Layers via Self-Assembly of Imidazole and Carboxylic acids. Crystal Growth & Design. (2001) 1(1), 18-29.
MacDonald, J.C., Dorrestein, P.C., Pilley, M.M., Foote, M.M., Lundburg, J.L., Henning, R.W., Schultz, A.J., Manson, J.L., Design of Layered Crystalline Materials Using Coordination Chemistry and Hydrogen Bonds. Journal of the American Chemical Society. (2000) 122(47), 11692-11702.
MacDonald, J.C., and Dorrestein, P.C., Design of robust molecular layers using ionic hydrogen bonds and metal-ligand interactions. Transactions of the American crystallographic association. (1999) Volume date 1998, 33, 117-127.
Pérez Morales TG, Ho TD, Liu WT, Dorrestein PC, Ellermeier CD. Production of the Cannibalism Toxin SDP is a multi-step process that requires SdpA and SdpB.
J Bacteriol. 2013 May 17.
Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore BS. Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic GeneCluster in Salinispora tropica. Chembiochem. 2013 May 27;14(8):955-62.
Rath CM, Yang JY, Alexandrov T, Dorrestein PC. Data-Independent Microbial Metabolomics with Ambient Ionization MassSpectrometry. J Am Soc Mass Spectrom. 2013 Apr 9.
Sanchez LM, Dorrestein PC. Analytical chemistry: Virulence caught green-handed.Nat Chem. 2013 Mar;5(3):155-7.
van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthaseaffects antibiotic sensitivity and skin abscess development. J Biol Chem. 2013 Mar 1;288(9):6417-26.
Watrous JD, Phelan VV, Hsu CC, Moree WJ, Duggan BM, Alexandrov T, Dorrestein PC. Microbial metabolic exchange in 3D.ISME J. 2013 Apr;7(4):770-80.
Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein PC, Milla ME. A highly efficient, high-throughput lipidomics platform for the quantitativedetection of eicosanoids in human whole blood. Anal Biochem. 2013 Feb 15;433(2):181-8.
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide naturalproducts: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan;30(1):108-60.
Ross AC, Xu Y, Lu L, Kersten RD, Shao Z, Al-Suwailem AM, Dorrestein PC, Qian PY, Moore BS. Biosynthetic multitasking facilitates thalassospiramide structural diversity inmarine bacteria. J Am Chem Soc. 2013 Jan 23;135(3):1155-62.
2012
Young TS, Dorrestein PC, Walsh CT. Codon randomization for rapid exploration of chemical space in thiopeptideantibiotic variants. Chem Biol. 2012 Dec 21;19(12):1600-10.
Song J, Liu X, Wu J, Blevitt JM, Dorrestein PC, Milla ME., A Highly Efficient, High-Throughput Lipidomics Platform for the Quantitative Detection of Eicosanoids in Human Whole Blood. Anal Biochem. 2012 Oct 25.
Hollands A, Gonzalez D, Leire E, Donald C, Gallo RL, Sanderson-Smith M, Dorrestein PC, Nizet V., A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides.J Biol Chem. 2012 Oct 4.
Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC., Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Anal Chem. 2012 Nov 6;84(21):9259-67.
Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick WH., Viequeamide a, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. J Nat Prod. 2012 Sep 28;75(9):1560-70.
Moree WJ, Phelan VV, Wu CH, Bandeira N, Cornett DS, Duggan BM, Dorrestein PC.,Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13811-6.
Hoefler BC, Gorzelnik KV, Yang JY, Hendricks N, Dorrestein PC, Straight PD., Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13082-7.
Yang JY, Phelan VV, Simkovsky R, Watrous JD, Trial RM, Fleming TC, Wenter R, Moore BS, Golden SS, Pogliano K, Dorrestein PC., Primer on agar-based microbial imaging mass spectrometry. J Bacteriol. 2012 Nov;194(22):6023-8.
Roberts AA, Schultz AW, Kersten RD, Dorrestein PC, Moore BS., Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. FEMS Microbiol Lett. 2012 Oct;335(2):95-103.
Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC., Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30;75(16):5069-76.
Guthals A, Watrous JD, Dorrestein PC, Bandeira N., The spectral networks paradigm in high throughput mass spectrometry. Mol Biosyst. 2012 Oct;8(10):2535-44.
Watrous J, Roach P, Alexandrov T, Heath BS, Yang JY, Kersten RD, van der Voort M, Pogliano K, Gross H, Raaijmakers JM, Moore BS, Laskin J, Bandeira N, Dorrestein PC., Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1743-52. Epub 2012 May 14.
Lamsa A, Liu WT, Dorrestein PC, Pogliano K., The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and induces autolysis. Mol Microbiol. 2012 May;84(3):486-500. doi: 10.1111/j.1365-2958.2012.08038.x. Epub 2012 Apr 2.
Xu Y, Kersten RD, Nam SJ, Lu L, Al-Suwailem AM, Zheng H, Fenical W, Dorrestein PC, Moore BS, Qian PY., Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc. 2012 May 23;134(20):8625-32. doi: 10.1021/ja301735a. Epub 2012 Apr 6.
Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V., Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20;287(17):13889-98. Epub 2012 Feb 27.
Rath CM, Dorrestein PC., The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes. Curr Opin Microbiol. 2012 Apr;15(2):147-54. Epub 2011 Dec 30. Review.
Phelan, V., Liu, WT., Pogliano, K., Dorrestein, PC., Microbial metabolic exchange--the chemotype-to-phenotype link. Nature Chemical Biology, 2011 Dec 15;8(1):26-35.
2011
Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC., A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Oct 9;7(11):794-802.
Liu WT, Kersten RD, Yang YL, Moore BS, Dorrestein PC., Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin in Streptomyces roseosporus. J Am Chem Soc. 2011 Nov 16;133(45):18010-3. Epub 2011 Oct 24.
Watrous JD, Dorrestein PC., Imaging mass spectrometry in microbiology. Nat Rev Microbiol. 2011 Aug 8;9(9):683-94.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG., ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs. Cell. 2011 Nov 11;147(4):773-88.
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP., Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 2011 Oct 26;478(7370):542-6.
Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C.,Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chem Biol. 2011 Aug 26;18(8):1021-31.
Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA., Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res. 2011 Oct 7;10(10):4505-12.
Esquenazi E, Daly M, Bahrainwala T, Gerwick WH, Dorrestein PC., Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation. Bioorg Med Chem. 2011 Nov 15;19(22):6639-44. Epub 2011 Jul 1.
Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH., Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod. 2011 Aug 26;74(8):1737-43. Epub 2011 Jul 13.
Mohimani H, Yang YL, Liu WT, Hsieh PW, Dorrestein PC, Pevzner PA., Sequencing cyclic peptides by multistage mass spectrometry. Proteomics. 2011 Sep;11(18):3642-50. Epub 2011 Aug 9.
Jones CS, Esquenazi E, Dorrestein PC, Gerwick WH., Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry. Bioorg Med Chem. 2011 Nov 15;19(22):6620-7. Epub 2011 Jun 14.
Gonzalez DJ, Haste NM, Hollands A, Fleming TC, Hamby M, Pogliano K, Nizet V, Dorrestein PC.,Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Microbiology. 2011 Sep;157(Pt 9):2485-92. Epub 2011 Jun 30.
Yang YL, Xu Y, Kersten RD, Liu WT, Meehan MJ, Moore BS, Bandeira N, Dorrestein PC.,Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5839-42. Epub 2011 May 13.
Jones AC, Monroe EA, Podell S, Hess WR, Klages S, Esquenazi E, Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR 3rd, Reinhardt R, Kube M, Burkart MD, Allen EE, Dorrestein PC, Gerwick WH, Gerwick L.,Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8815-20. Epub 2011 May 9.
Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH., Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One. 2011 Apr 12;6(4):e18565.
Kalaitzis JA, Cheng Q, Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, Moore BS.,Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem. 2011 Nov 15;19(22):6633-8. Epub 2011 Apr 16.
Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore BS., Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol. 2011 Jun;77(11):3617-25. Epub 2011 Apr 15.
Mevers E, Liu WT, Engene N, Mohimani H, Byrum T, Pevzner PA, Dorrestein PC, Spadafora C, Gerwick WH., Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod. 2011 May 27;74(5):928-36. Epub 2011 Apr 13.
Engene N, Choi H, Esquenazi E, Rottacker EC, Ellisman MH, Dorrestein PC, Gerwick WH., Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol. 2011 Jun;13(6):1601-10. Epub 2011 Apr 7.
Esquenazi E, Jones AC, Byrum T, Dorrestein PC, Gerwick WH., Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proc Natl Acad Sci U S A. 2011.
Bruand J, Sistla S, Mériaux C, Dorrestein PC, Gaasterland T, Ghassemian M, Wisztorski M, Fournier I, Salzet M, Macagno E, Bafna V., Automated Querying and Identification of Novel Peptides using MALDI Mass Spectrometric Imaging. J Proteome Res. 2011 Feb 18.
Watrous JD, Alexandrov T, Dorrestein PC., The evolving field of imaging mass spectrometry and its impact on future biological research. J Mass Spectrom. 2011 Feb;46(2):209-22. doi: 10.1002/jms.1876.
Dorrestein PC, Carroll KS., 'Omics' of natural products and redox biology., Curr Opin Chem Biol. 2011 Feb;15(1):3-4.
Yang JY, Karr JR, Watrous JD, Dorrestein PC., Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes. Curr Opin Chem Biol. 2011 Feb;15(1):79-87.
Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein PC., FT-ICR-MS Characterization of Intermediates in the Biosynthesis of the α-Methylbutyrate Side Chainof Lovastatin by the 277 kDa Polyketide Synthase LovF. Biochemistry. 2010
Meier JL, Patel AD, Niessen S, Meehan M, Kersten R, Yang JY, Rothmann M, Cravatt BF, Dorrestein PC, Burkart MD, Bafna V., Practical 4'-phosphopantetheine active site discovery from proteomic samples. J Proteome Res. 2011 Jan 7;10(1):320-9.
Mohimani H, Liu WT, Yang YL, Gaud Ncio SP, Fenical W, Dorrestein PC, Pevzner PA., Multiplex de novo sequencing of Peptide antibiotics. J Comput Biol. 2011 Nov;18(11):1371-81. Epub 2011 Oct 28.
Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA., Cycloquest: Identification of Cyclopeptides via Database Search of Their Mass Spectra against Genome Databases. J Proteome Res. 2011 Oct 28.
2010
Liu X, Inbar Y, Dorrestein PC, Wynne C, Edwards N, Souda P, Whitelegge JP, Bafna V, Pevzner PA., Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach. Mol Cell Proteomics. 2010 Dec;9(12):2772-82.
Kersten RD, Dorrestein PC., Metalloenzymes: Natural product nitrosation. Nat Chem Biol. 2010 Sep;6(9):636-7.
O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM., Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS One. 2010 Jul 22;5(7):e11716.
Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG., PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22;466(7305):508-12.
Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez D, Ellermeier CD, Straight PD, Pevzner PA, Pogliano J, Nizet V, Pogliano K, Dorrestein PC., Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16286-90. Epub 2010 Aug 30.
Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC., Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 3;285(36):28220-8.
Leao PN, Pereira AR, Liu WT, Ng J, Pevzner PA, Dorrestein PC, Konig GM, Vasconcelos VM, Gerwick WH., Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11183-8.
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL., A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11;285(24):18516-27.
Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y.,Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis. J Am Chem Soc. 2010.
Watrous J, Hendricks N, Meehan M, Dorrestein PC., Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry. Anal Chem. 2010 Mar 1;82(5):1598-600. PMID: 20121185
Jones AC, Gerwick L, Gonzalez D, Dorrestein PC, Gerwick WH., Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol. 2009 Dec 1;9:247. PMID: 19951434
Watrous, J., Burns, K. Liu, W., Patel, A., Hook, V. Bafna, V. Barry3rd C. E., Bark, S., Dorrestein P. C., Expanding the Mycobacterial Pupylome. Molecular Biosystems, 2010 Feb;6(2):376-85.
2009
Yang, Y.L., Xu, Y., Straight, P., Dorrestein, P.C., Translating metabolic exchange with imaging mass spectrometry. Nature Chemical Biology ,2009 Dec;5(12):885-7.
Esquenazi, E., Yang, Y-L., Watrous, J., Gerwick, W. H., Dorrestein, P. C., Imaging Mass Spectrometry of Natural Products. Natural Product Reports, 2009, Dec;26(12):1521-34. Epub 2009 Nov 9. Review. (featured on the cover)
Ng,J., Bandeira, N.,Liu, W.T. Ghassemian, M., Simmons, T. L., Gerwick, W.H., Linington, R., Dorrestein P.C., Pevzner, P., Dereplication and De Novo Sequencing of Nonribosomal Peptides. Nature Methods, (2009), 6(8):596-9. PMID: 19597502
Taniguchi M., Nunnery J.K., Engene N., Esquenazi E., Byrum T., Dorrestein P.C., Gerwick W.H.Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine Cyanobacterium Lyngbya majuscula. Nat. Prod. 2009, PMID: 19839606
Kersten R. D, Dorrestein, P. C., Secondary Metabolomics: Natural Products Mass Spectrometry Goes Global. ACS chemical Biology, (2009), Invited commentary, 4(8):599-601.PMID: 19817465
Xie X., Meehan M.J., Xu W., Dorrestein P.C., Tang Y., Acyltransferase mediated polyketide release from a fungal megasynthase. Journal of the American Chemical Society, (2009) 131, 8388-9. PMID: 19530726
Hughes, C, Yang, Y-L, Liu, W-T., Dorrestein, P. C. *, La Clair*, Fenical, W.,* Elucidation of the binding of marinopyrrole A to actin by dye transfer. Journal of the American Chemical Society, (2009),131(34):12094-6. PMID: 19673475
Esquenazia E., Dorrestein P. C, Gerwick W. H., Probing marine natural product defenses with DESI-imaging mass spectrometry. Proc. Natl. Acad. Sci. USA. (2009, comm.), 106, 7269-70. PMID: 19416917
Liu, W.T., Ng, Julio, Meluzzi, D., Bandeira, N., Gutierrez, M., Simmons, T., Schultz, A., Linington, R., Moore, B., Gerwick, W., Pevzner, P., Dorrestein, P. C., The structural characterization of cyclic non-ribosomal peptides by tandem mass spectrometry. Analytical Chemistry (2009) 106, 7269-70. PMID: 19413302
Kersten R. D., Meehan M., Dorrestein P. C., Applications of Modern Mass Spectrometry Techniques for the Characterization of Biosynthetic Pathways of Natural Products.Comprehensive Natural Products Chemistry Second Edition. (2009).
OHayre M., Salanga C. L., Dorrestein P.C. and Handel T., Phosphoproteomic Analysis of Chemokine Signaling Networks. Methods in Enzymology (2009), 460,331-46. PMID: 19446733
Burns KE, Liu WT, Boshoff HI, Dorrestein PC, Barry CE 3rd., Proteasomal protein degradation in mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. J Biol Chem. 2009 Jan 30;284(5):3069-75.
2008
Esquenazi, E., Coates, C., Simmons, L., Gonzalez, D., Gerwick, W.H., Dorrestein, P.C., Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Molecular BioSystems. 2008 Jun;4(6):562-70.
Simmons, T. L., Coates R.C., Clark B. R., Engene N., Gonzalez D., Esquenazi, E., Dorrestein P. C., Gerwick W. H., Biosynthetic Origin of Natural Products Isolated from Marine Microorganism-Invertebrate Assemblages. Proc. Natl. Acad. Sci. USA. 2008 Mar 25;105(12):4587-94.
Zhang, J., Van Lanen, S. G., Ju, J., Liu, W. Dorrestein, P.C., Li, W., Kelleher, N. L., Shen, B. A.,Phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. USA. 2008 Feb 5;105(5):1460-5.
Meluzzi, D., Zheng, W.H., Hensler, M., Nizet, V., Dorrestein, P. C., Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorganic & Medicinal Chemistry Letters. 2008 May 15;18(10):3107-11.
Hanes JW, Burns KE, Hilmey DG, Chatterjee A, Dorrestein PC, Begley TP., Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-52.
Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G., A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14;29(5):563-76.
Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE., Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.
Pouwels LJ, Zhang L, Chan NH, Dorrestein PC, Wachter RM., Kinetic isotope effect studies on the de novo rate of chromophore formation in fast- and slow-maturing GFP variants. Biochemistry. 2008 Sep 23;47(38):10111-22.
2007
Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT., Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol. (2007) Jul;14(7):835-46.
Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore BS., Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem. (2007) Jun 1;282(22):16362-8.
Yin, J., Straight, P.D., Hrvatin, S., Dorrestein, P. C., Bumpus, S., Jao, C., Kelleher, N. L., Kolter, R., Walsh, C.T., Genome-wide high throughput mining of natural product biosynthetic gene clusters by phage display. Chemistry and Biology,(2007) Mar;14(3):303-12.
2006
Garneau-Tsodikova, S., Dorrestein, P.C., Kelleher, N.L., Walsh, C. T., Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society (2006) 128(39); 12600-12601.
Dorrestein, P.C., Kelleher, N.L., Dissecting Non-ribosomal and Polyketide Biosynthetic Machineries Using Electrospray Ionization Fourier-Transform MassSpectrometry. Nat Prod Rep. (2006) Dec;23(6):893-918.
Dorrestein P.C., Bumpus S. B., Calderone C. T., Garneau-Tsodikova S., Aron Z. D., Straight P.D., Kolter R., Walsh C. T. and Kelleher N. L., Facile Detection of Acyl- and Peptidyl- intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions During Tandem Mass Spectrometry. Biochemistry (2006) 45 (6), 1537 -1546.
Dorrestein, P.C., Van Lanen, S. G., Li, W. Zhao, C., Deng, Z., Shen, B., Kelleher, N.L., The Bifunctional Glyceryl Transferase/Phosphatase OzmB Belonging to the HAD Superfamily That Diverts 1,3-Bisphosphoglycerate into Polyketide Biosynthesis. Journal of the American Chemical Society (2006) 128 (32), 10386 10387.
Calderone, C.T., Kowtoniuk, W.E., Kelleher, N.L., Walsh, C.T., Dorrestein, P.C., Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of B. subtilis. Proc. Natl. Acad. Sci. USA. (2006) 103, 8977-8982.
Dorrestein, P.C., Blackhall, J., Straight, P.D., Fischbach, M.A., Garneau-Tsodikova, S., Edwards, D.J., McLaughlin, S., Lin, M., Gerwick, W.H., Kolter, R., Walsh, C.T., Kelleher, N.L., Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry. Biochemistry (2006) 45(6), 1537-1546.
Howarth, M., Chinnapen, D.J.F., Gerrow, K., Dorrestein, P.C., Grandy, M.R., Kelleher, N.L., El-Husseini, A., Ting, A.Y., A Monovalent Streptavidin with a Single Femtomolar Biotin Binding Site. Nature Methods (2006) 3(4), 267-273.
Hicks, L.M., Mazur, M.T., Miller, L.M., Dorrestein, P.C., Schnarr, N.A., Khosla, C., Kelleher, N.L.,Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides using Fourier-Transform Mass Spectrometry. ChemBiochem (2006) 7, 904-907.
Van Lanen S.G., Lin S., Dorrestein P.C., Kelleher N.L., Shen B., Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Biol. Chem. (2006) 281, 29633-40.
2005
Dorrestein, P.C., Yeh, E., Garneau-Tsodikova, S., Kelleher, N.L., Walsh, C.T., Dichlorination of a Pyrrolyl-S-Carrier protein by FADH2-Dependent Halogenase PltA During Pyoluteorin Biosynthesis. Proceedings of the National Academy of Sciences of the United States of America (2005) 102(39), 13843-13848.
Aron, Z.D., Dorrestein, P.C., Blackhall, J.R., Kelleher, N.L., Walsh, C.T., Characterization fo the New Tailoring Domain in Polyketide Biogenesis: The Amine Transferase Domain of MycA in the Mycosubtilin Gene Cluster. Journal of the American Chemical Society (2005) 127(43), 14986-14987.
Van Lanen, S.G., Dorrestein, P.C., Christenson, S.D., Liu, W., Ju, J., Kelleher, N.L., Shen, B.,Biosynthesis of the b -Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring b-Amino Acyl-S-carrier Protein Intermediates. Journal of the American Chemical Society. (2005) 127(33), 11594-5.
Garneau, S., Dorrestein, P.C., Kelleher, N.L., and Walsh, C.T., Characterization of the Formation of the Pyrrole Moiety during Clorobiocin and Coumermycin A1 Biosynthesis. Biochemistry. (2005) 44, 2770-2780.
Zhai, H., Dorrestein, P.C., Chatterjee, A., Begley, T.P., McLafferty, F.W., Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. Journal of American Society of Mass. Spectrometry. (2005) 16(7), 1052-9.
Burns, K.C., Baumgart, S., Dorrestein, P.C., Zhai, H., McLafferty, F.W., Begley, T.P., Reconstitution of a New Cysteine Biosynthetic Pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society. (2005) 127(33), 11602-3.
Dorrestein P.C., and Begley, T.P., Oxidative cascades: a facile biosynthetic stategy for the assembly of complex molecules. Bioorganic Chemistry. (2005) 33(3), 136-148. (review).
2004
Settembre E.C., Dorrestein, P.C., Zhai,H., Chatterjee, A., McLafferty, F.W., Begley, T.P., Ealick S.E., Structure of the ThiS/ThiG complex Essential for Thiamin Biosynthesis in Bacillus subtilis.Biochemistry. (2004) 43(37), 11647-57.
Dorrestein, P.C., Zhai, H., McLafferty F.W., and Begley, T.P., The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin (Vitamin B1): The Sulfur Transfer Mediated by the Sulfur Carrier Protein ThiS. Chemistry and Biology. (2004) 11(10), 1373-81.
Dorrestein, P.C., Zhai, H., Taylor, S., McLafferty, F., and Begley, T.P., The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase.Journal of the American Chemical Society. (2004)126(10), 3091-6.
2003
Kurnasov, O., Jablonski, L., Polanuyer, B., Dorrestein, P.C., Begley, and T.P., Ostermann, A.,Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS microbiology letters. (2003) 227(2), 219-227.
Park, J., Dorrestein, P.C., Zhai, H., Kinsland, C., McLafferty, F.W., and Begley, T.P., Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. (2003) 42, 12430-12438.
Dorrestein, P.C., Poole, K., and Begley, T.P., The formation of the pyoverdine chromophore by an oxidative cascade. Organic Letters. (2003) 5(13), 2215-2217.
Maggio-Hall, L., Dorrestein, P.C., Begley T.P., Escalante-Semerena J. C., Formation of the Dimethylbenzimidazole Ligand of Coenzyme B12 under physiological conditions by a facile oxidative cascade. Organic letters. (2003) 5(13), 2211-2213.
Settembre, E.C., Dorrestein, P.C., Park, J., Augustine, A., Begley, T.P., Ealick, S.E., Structural and Mechanistic studies of ThiO, a Glycine Oxidase Essential for Thiamin Biosynthesis in Bacillus subtilis. Biochemistry. (2003) 42(10), 2971-2981.
1999-2002
Anand, R., Dorrestein, P.C., Kinsland, C., Begley, T.P., Ealick, S.E., Structure of Oxalate Decarboxylase From Bacillus subtilis at 1.75 Resolution. Biochemistry. (2002) 41(24), 7659-7669.
Begley, T.P., Kinsland, C., Mehl, R.A., Ostermann, A., and Dorrestein, P.C. The Biosynthesis of Nicotinamide Adenine Dinucleotides in Bacteria. Vitamins and Hormones (San Diego, CA, United States). (2001) 61,103-119 (review).
Mansour, G., Creedon, W., Dorrestein, P.C., Maxka, J., MacDonald, J.C., Helburn, R., Synthesis and Physical Characterization of Some New Hydrophobic Forms of the Solvatochromic N,N-dialkyl-p-nitroanilines. Journal of Organic Chemistry. (2001) 66(11), 4050-4054.
MacDonald, J.C., Dorrestein, P.C., Pilley, M.M., Design of Supramolecular Layers via Self-Assembly of Imidazole and Carboxylic acids. Crystal Growth & Design. (2001) 1(1), 18-29.
MacDonald, J.C., Dorrestein, P.C., Pilley, M.M., Foote, M.M., Lundburg, J.L., Henning, R.W., Schultz, A.J., Manson, J.L., Design of Layered Crystalline Materials Using Coordination Chemistry and Hydrogen Bonds. Journal of the American Chemical Society. (2000) 122(47), 11692-11702.
MacDonald, J.C., and Dorrestein, P.C., Design of robust molecular layers using ionic hydrogen bonds and metal-ligand interactions. Transactions of the American crystallographic association. (1999) Volume date 1998, 33, 117-127.